Sang Jin Lee, Ph.D.
Instructor

SHORT BIOGRAPHIC SKETCH: Dr. Sang Jin Lee was born and raised in Korea. He received his Ph.D. in Chemical Engineering at Hanyang University, Korea, in 2003 and took a postdoctoral fellowship in the Laboratories for Tissue Engineering and Cellular Therapeutics at Children’s Hospital Boston and the Institute for Regenerative Medicine at Wake Forest University Health Sciences where he is currently a faculty member.

SYNOPSIS OF AREA OF INTEREST: Fabrication and development of biomaterials including natural and synthetic origins; cell-biomaterial interactions; surface modification; drug and protein delivery systems.
DETAILED AREA OF INTEREST: Biomaterials have played an enormous role in virtually every application in tissue engineering and regenerative medicine that support engineered tissues until repairing the function and structural maintenance. Dr. Lee is working on fabrication and development of three-dimensional biomaterials for every tissue engineered construct. He is particularly interested in the target specific scaffold (TSS) for controlled cell differentiation in vivo. TSS project is based on stem cell recruitment into the implanted biomaterials. Almost every tissue in the body contains some type of stem or progenitor cell, including bone marrow, circulating blood, skin, fat, muscle, brain, heart and liver. If it is possible to recruit the cells with multilineage potential into a biomaterial, then it may be possible to enrich the infiltrate with such cell types and control their fate, provided the proper substrate-medicated signaling can be imparted into the biomaterial. If we can delineate the putative mechanisms for these events and build them into a new class of biomaterials, the potential for such a paradigm shift in regenerative medicine may emerge. Recently, Dr. Lee has been involved in engineering tissues, including blood vessels, kidney, cartilage, bone, muscle and liver.

PUBLICATIONS:
Lee SJ, Yoo JJ, Lim G, Atala A, and Stitzel J. In vitro evaluation of electrospun nanofiber scaffolds for vascular graft application. J. Biomed Mater Res A 2006;in press.

Lee SJ, Lim G, Lee J-W, Atala A, and Yoo JJ. In vitro evaluation of a poly(lactide-co-glycolide)-collagen composite scaffold for bone regeneration. Biomaterials 2006;27(18):3466.

Stitzel JD, Liu J, Lee SJ, Komura M, Berry J, Soker S, Lim G, van Dyke M, Czerw R, Yoo JJ, and Atala A. Controlled fabrication of a biological vascular substitute. Biomaterials 2006;27(7):1088.

Lee SJ, Choi JS, Park KS, Khang G, Lee YM, and Lee HB. Surface roughness on MG63 osteoblast-like cells to the polycarbonate membrane surfaces with different micropore sizes. Biomaterials 2004;25(19):4699.

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