Barry I. Freedman, M.D., Ph.D., John H. Felts, III, Distinguished Professor of Internal Medicine and Nephrology
Chief, Section on Nephrology
Dr. Freedman received his B.S. from Brooklyn College, CUNY, in 1980 and his M.D. from Downstate Medical Center, SUNY, in 1984. He completed his internship and residency at Eastern Virginia Graduate School of Medicine, which was followed by a fellowship at Bowman Gray School of Medicine from 1987-1989. He is board certified in internal medicine, specializing in nephrology.

SYNOPSIS OF AREA OF INTEREST:: Teaching: Clinical Nephrology, Hypertension, Atherosclerosis, and Type 2 Diabetes; Research: Genetic Susceptibility to Atherosclerosis and Hypertensive/Diabetic Nephropathy; Ethnic Differences in Kidney Disease and Atherosclerosis; Clinical: General Nephrology, Kidney Transplantation and Cardiovascular Disease.

DETAILED AREA OF INTEREST: Dr. Freedman and his associates in the Center for Human Genomics and Department of Public Health Sciences have worked at the WFUSM for the past 16 years to identify genes that cause common kidney diseases, atherosclerosis, essential hypertension and type 2 diabetes mellitus. His group first detected the protein tyrosine phosphatase 1B gene association with type 2 diabetes mellitus and with atherosclerosis, as well as the carnosinase 1 gene association in type 2 diabetic nephropathy. He continues to explore interactions between genetic and environmental factors involved in complex kidney and cardiovascular diseases and type 2 diabetes mellitus.

PUBLICATIONS:

Lange L, Bowden DW, Langefeld CD, Wagenknecht LE, Carr JJ, Rich SS, Riley WA, Freedman BI. Heritability of carotid artery intimal medial thickness in type 2 diabetes. Stroke 2002; 33:1876-1881.

Freedman BI, Langefeld DC, Rich SS, Valis CJ, Sale MM, Williams AH, Brown WM, Beck SR, Hicks PJ, Bowden DW. A genome wide scan for ESRD in black families enriched for nondiabetic nephropathy. J Am Soc Nephrol 2004; 15:2719-2727.

Engeler Dusel JA, Burdon KP,Hicks PJ, Hawkins G, Bowden DW, Freedman BI. Identification of Podocin (NPHS2) gene mutations in African Americans with hypertension-associated end-stage renal disease. Kidney Int 2005; 68(1):256-262.

Freedman BI, Langefeld CD, Lohman K, Bowden DW, Carr JJ, Rich SS, Wagenknecht LE. The relationship between albuminuria and cardiovascular disease in type 2 diabetes. J Am Soc Nephrol 2005; 16:2156-2616.

Freedman BI, Hsu FC, Langefeld CD, Rich SS, Herrington DM, Carr JJ, Xu J, Bowden DW, Wagenknecht LE. The impact of ethnicity and gender on subclinical cardiovascular disease: The Diabetes Heart Study. Diabetologia 2005; 48:2511-2518.

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